Group Companies

Otsuka Pharmaceutical Co., Ltd. Manufacture, sales, import/export of pharmaceuticals, clinical testing and medical equipment, food products and cosmetics Otsuka Pharmaceutical Factory, Inc. Manufacture and sale of drugs (mainly clinical nutrition products), medical devices, and functional foods Taiho Pharmaceutical Co., Ltd. Manufacture, sales, import and export of pharmaceuticals and medical devices Otsuka Warehouse Co., Ltd. Warehousing and transport business Otsuka Chemical Co., Ltd. Manufacture and sales of chemical products Otsuka Foods Co., Ltd. Manufacture, sales, and import of foods and beverages Otsuka Medical Devices Co., Ltd. R&D, manufacture, and sales of medical devices and all related operations, as well as medical device operational management for companies within the Otsuka group Otsuka Business Support Co., Ltd. Shared service business a.trax, inc. Travel agency Otsuka Electronics Co., Ltd. Manufacture and sales of analysis and measurement equipment Otsuka Wellness Vending Co., Ltd. Sales of nutritional products and beverages through vending machine Nippon Pharmaceutical Chemicals Co., Ltd. Research and development and manufacture of pharmaceutical intermediates Otsuka Mechatronics Co., Ltd. Manufacture and sales of various types of testing equipment such as vehicle headlight testers Otsuka Digital Health Co., Ltd. Providing IT solution services Heartful Kawauchi Co., Ltd. Office support, manufacturing support, and agriculture business Otsuka Techno Corporation Manufacture and sales of synthetic resin molded products EN Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products J.O. Pharma Co., Ltd. Manufacture and sales of pharmaceutical products Otsuka Ridge Co., Ltd. Operation of Hotel Ridge and California Table Lilium Otsuka Co., Ltd. Research and development, manufacturing, and marketing of medical devices and related products Otsuka Clinical Solutions, Inc. Development and manufacture of medical equipment and devices, development, manufacture and sale of healthcare products Okayama Taiho Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Taiho Innovations Ltd. Venture capital business; incubation business; contract research and development services for pharmaceuticals and diagnostics; and consulting services related to these activities ARIRGE CO., LTD. Provision of medical and healthcare information and software, platform business, etc. Otsuka Packaging Industries Co., Ltd. Manufacture and sales of paper products Otsuka Harumi-development Co., Ltd. Rental space and rental office business Otsuka Ohmi Ceramics Co., Ltd. Planning, design, production and construction of large ceramic boards, ceramic board masterpiece art, ceramic walls, reliefs, terracotta, OT ceramics, ceramic portraits and ceramic sign boards Higashiyama Film Co., Ltd. Processing and marketing of functional film Otsuka-MGC Chemical Company, Inc. Manufacture and sales of chemical products hakkai Co., Ltd. Precision plastic mold design and manufacturing, engineering plastic molding processing, various coil winding and assembly processing, and automatic machines and precision jig and tool manufacturing JIMRO Co., Ltd. Manufacture, sales, rental, export, import, research and development of medical devices Earth Corporation ^* Manufacturing, marketing, and import/export of pharmaceutical products, quasi-drugs, medical tools, household products, etc. Earth Environmental Service Co., Ltd. ^* General environmental health management Kitasato-Otsuka Biomedical Assay Laboratories Co., Ltd. ^* Provision of clinical testing services Tokushima Vortis Co., Ltd. ^* Provision of soccer entertainment, soccer school, etc. Nichiban Co., Ltd. ^* Manufacturing and sales of adhesive tape for medical, stationary, industrial use

Otsuka Australia Pharmaceutical Pty Ltd. Import and sales of pharmaceutical proudcts Taiho Pharma Oceania Pty Ltd. Sales, regulatory affairs, and medical affairs of pharmaceutical products Otsuka (China) Investment Co., Ltd. Holding company Sichuan Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Zhejiang Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Otsuka Beijing Research Institute Clinical development and research of pharmaceutical products Tianjin Otsuka Beverage Co., Ltd. Manufacture and sales of soft drinks and beverages Otsuka Sims (Guangdong) Beverage Co., Ltd. Manufacture and sales of soft drinks Pharmavite (Shanghai) Nutrition Technology Co., Ltd. Sales of nutritional products Otsuka Electronics (Suzhou) Co., Ltd. Import/exportand sales of analysis and measurement equipment China Otsuka Pharmaceutical Co., Ltd. ^* Manufacture and sales of pharmaceutical products Guangdong Otsuka Pharmaceutical Co., Ltd. ^* Manufacture and sales of pharmaceutical products Suzhou Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Nanjing Otsuka Techbond Techno Co., Ltd. Manufacture and sales of synthetic resin molded products（3-layer film and 5-layer film） Leshan Otsuka Techno Co., Ltd. Manufacture and sales of plastic molded products and packaging materials for food and pharmaceutical products Taiho Pharmaceutical of Beijing Co., Ltd. Providing information on pharmaceuticals and clinical development work Zhangjiagang Otsuka Chemical Co., Ltd. Manufacture and marketing of flaky titanate and special compounds Otsuka Chemical (Shanghai) Co., Ltd. Import/export and sales of chemical products Otsuka Material Science & Technology (Shanghai) Co., Ltd. Research and development, and assessment of high-valued-added compounds and combination agents Otsuka South China Precision Instruments (Shenzhen) Co., Ltd. Manufacture and sales of plastic precision parts Noble Skill Limited Sales of resin, resin parts and assembling parts Shanghai Otsuka Foods Co., Ltd. Manufacture and sales of food products Otsuka Pharmaceutical (H.K.) Ltd. Sales of pharmaceutical products and beverages Taiwan Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products King Car Otsuka Co., Ltd. ^* Manufacture and sales of beverages and foods Otsuka Tech Electronics Co., Ltd. Manufacture, sales, and maintenance of analysis and measurement equipment Egypt Otsuka Pharmaceutical Co., S.A.E. Manufacture and sales of pharmaceutical products Arab Otsuka Nutraceuticals Co., S.A.E. Sales of health beverages Otsuka Al-Obour Pharmaceutical Egypt S.A.E. Sales of IV solutions Otsuka Gypto Pharmaceutical Egypt S.A.E. ^* Sales of pharmaceutical producs including IV solutions Otsuka Nutraceutical India Private Limited Manufacture, sale, and import (and sale) of food and beverages Otsuka Pharmaceutical India Private Limited Manufacture and sales of basic infusion and clinical nutrition products Otsuka Chemical (India) Private Limited Manufacture and sales of chemical products PT Otsuka Indonesia Manufacture and sales of pharmaceutical products PT Amerta Indah Otsuka Manufacture and sales of soft drinks and beverages PT Otsuka Distribution Indonesia Conducting business in large trading in general, including trade in import and export PT Widatra Bhakti Manufacture and sales of pharmaceutical products PT Otsuka Jaya Indah Purchasing and sales of beverages and agricultural products PT Merapi Utama Pharma Purchasing and sales of pharmaceutical products and medical equipment PT Lautan Otsuka Chemical Manufacture and sales of chemical products Otsuka Pharmaceuticals (Malaysia) Sdn. Bhd. Sales of pharmaceutical products Otsuka Nutraceutical Mexico S.A. de C.V. Import and sales of beverages and food products Otsuka Myanmar Company Ltd. Marketing and distribution of nutraceutical products Diatranz Otsuka Limited Development and manufacturing of Xenotransplantation products OTSUKA NIGERIA NUTRACEUTICALS COMPANY LIMITED Manufacture, import, and sales of beverages Otsuka Pakistan Ltd. Manufacture and sales of pharmaceutical products Otsuka (Philippines) Pharmaceutical, Inc. Manufacture and sales of pharmaceutical and nutritional products OTSUKA-SOLAR Philippines Incorporated Import and sales of beverages and foods Otsuka Singapore Pte. Ltd. Manufacture, sale, export, and import of food additives Otsuka Pharmaceuticals (Singapore) Pte. Ltd. Sales of pharmaceutical products Taiho Pharma Asia Pacific Pte. Ltd. Import and sales of pharmaceutical products Korea Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Otsuka Electronics Korea Co., Ltd. Import, manufacture and sales of analytical instruments and measuring instruments Dong-A Otsuka Co., Ltd. ^* Manufacture and sales of beverages and foods KOC Co., Ltd. Manufacture and marketing of hydrazine Otsuka Nutraceutical (Thailand) Co., Ltd. Manufacture, sales, import, and export of beverages and food products Thai Otsuka Pharmaceutical Co., Ltd. ^* Manufacture and sales of pharmaceutical products Abdi Ibrahim Otsuka Pharmaceutical Company Sales of pharmaceutical products Otsuka Nutraceutical Vietnam Co., Ltd. Sales of beverages and foods Otsuka Pharmaceutical Vietnam Joint Stock Company Manufacture and sales of clinical nutrition products Otsuka Techno Vietnam Co., Ltd. Manufacture and sales of packaging materials and electronic parts

Otsuka Canada Pharmaceutical, Inc. Sales and marketing of pharmaceutial products Mindset Pharma, Inc. Drug discovery research and development Daiya Foods Inc. Manufacture and sales of plant-based foods Taiho Pharma Canada, Inc. Preparation for anticancer drug sales Otsuka Global Insurance, Inc. Reinsurance underwriting for the Otsuka Group Otsuka America, Inc. Holding company Otsuka America Pharmaceutical, Inc. Manufacture and sales of pharmaceutical products Otsuka Pharmaceutical Development & Commercialization, Inc. Clinical development and commercialization of pharmaceutical products Cambridge Isotope Laboratories, Inc. Manufacture and sales of reagents for research, such as stable isotopes CIL Isotope Separations, LLC Production facility for the separation of isotopes A&P Inphatec, LLC Research and development, manufacture and sales of bio-pesticides Visterra, Inc. Research and development of pharmaceutical products Otsuka Nutraceutical Emerging Ventures LLC Nutraceuticals venture capital Otsuka Precision Health, Inc. Software and services to improve management of mental healthcare systems Jnana Therapeutics Inc. Research and development of pharmaceutical products Pharmavite LLC Manufacture and sales of nutritional products FoodState, Inc. Production and sales of natural and whole food supplements Bonafide Health, LLC Manufacture, and sales of products for women's health Crystal Geyser Water Company Manufacture and sales of soft drinks and beverages Ridge Vineyards, Inc. Manufacture and sales of wine CG Roxane LLC ^* Manufacture and export of soft drinks and beverages Otsuka Pharmaceutical Factory America, Inc. Manufacture, sale, import/export, technology transfer of drugs, medical devices, and functional foods Otsuka ICU Medical LLC Manufacture, import, and sale of pharmaceuticals, mainly basic IV solutions and clinical nutrition products, and medical devices Taiho Oncology, Inc. Clinical development and commercialization of anticancer drugs Taiho Ventures, LLC Venture Capital Cullinan Pearl Corporation Clinical development of anticancer drugs Otsuka Chemical America, Inc. Manufacturing and selling Terracess (fiber-free potassium titanate) Recor Medical, Inc. Research and development, manufacturing, and sales of medical devices

Nutrition & Sante Benelux S.A. Sales of functional and dietetic foods Interpharma Praha, a.s. Manufacture and sales of pharmaceutical and nutrition products Otsuka Pharmaceutical France SAS Purchasing and sales of pharmaceutical products Nardobel SAS Holding company Nutrition & Sante SAS Manufacturing and distributing of functional and dietetic foods ALMA S.A. ^* Holding company of Alma Group, which manufactures and markets of spring water and mineral water Otsuka Holdings Europe GmbH Shared service business Otsuka Pharma GmbH Purchasing and sales of pharmaceutical products Advanced Biochemical Compounds GmbH Development and manufacturing of chemicals for nuclear medicine applications Otsuka Novel Products GmbH Research and development related to tuberculosis Recor Medical Europe GmbH Sales of medical devices Otsuka Pharmaceutical Italy S.r.l. Sales of pharmaceutical products Nutrition & Sante Italia SpA Sales of functional and dietetic foods Otsuka Pharmaceutical Netherlands BV Marketing Authorisation Holder for Otsuka European entities Otsuka Pharmaceutical, S.A. Manufacture and sales of pharmaceutical products Nutrition & Sante Iberia SL Sales of functional and dietetic foods Hebron S.A. Manufacture and sales of industrial chemicals Trocellen Iberica S.A. Manufacture and marketing of polyolefin foams Otsuka Pharma Scandinavia AB Purchasing and sales of pharmaceutical products Otsuka Pharmaceutical (Switzerland) GmbH Sales of pharmaceutical products Taiho Oncology Europe GmbH Development and sales of pharmaceutical products Araris Biotech AG Research and development of pharmaceutical products Otsuka Pharmaceutical Europe Ltd. Manufacture and sales of pharmaceutical products Otsuka Pharmaceuticals (U.K.) Ltd. Purchasing and sales of pharmaceutical products Astex Therapeutics, Ltd. Drug discovery research and development Veryan Holdings Ltd. Holding company Veryan Medical Ltd. Research and development, manufacturing, and sales of Peripheral Artery Stent